The Past and Present of HCQ

Written by Gravitational Wave

It is probably the first time in modern history that a kind of medicine is stigmatized as a victim of politic game. Yes, you know what I am going to talk about, hydroxychloroquine (HCQ). It is a long story. Please read it patiently, I believe you will come to your own judgment.

Antimalarials have been used as slow-acting drugs to treat rheumatism for more than a century. It originated from the bark of Cinchona tree in Peru. In 1820, two French pharmacists successfully extracted quinine, the earliest antimalarial drug in history, from the bark of cinchona. In 1894, a physician in London, England, used quinine to treat discoid lupus erythematosus (DLE) for the first time and achieved remarkable results. This was the first time that scientists used antimalarials to treat immune diseases.

Chloroquine is a chemically synthesized antimalarial drug based on quinine. With the development of science, scientists have discovered that chloroquine has obvious toxic and side effects while exerting therapeutic effects.So, in 1944, scientists developed a new type of antimalarial drug, hydroxychloroquine (HCQ), based on chloroquine. The difference between it and chloroquine is that a hydroxyl group is added to chloroquine, which has similar therapeutic effects but significantly reduces side effects.

Since then, hydroxychloroquine has been widely used as an immunosuppressant in the treatment of rheumatic diseases. Therefore, hydroxychloroquine is an old drug with a history of 70 years. Hydroxychloroquine is one of the most efficacious, safe and cost–effective medicines listed on “WHO Model List of Essential Medicines”.CDC says HCQ can be “safely taken by pregnant women and children.

We all know that hydroxychloroquine has a reliable effect in the treatment of malaria and lupus erythematosus, but why can hydroxychloroquine be used to treat COVID-19?

The essence of rheumatic immune diseases is chronic inflammatory diseases, which are caused by the excessive activation of the immune system, which produces a variety of antibodies, causes a storm of cellular inflammatory factors and kills one’s own healthy tissues. In COVID-19 cases, SARS-COV-2 enters host cells, activates the immune system in the body, it can also triggers a storm of cellular inflammatory factors, and causes multiple organ failure. Long-term studies have shown that hydroxychloroquine can inhibit the excessive activation of the system and inhibit inflammatory cells from producing inflammatory factor storms. Therefore, the use of hydroxychloroquine to treat COVID-19 is an old drug and a new use, but it has a solid theoretical basis.

The first one who put forward that usinghydroxychloroquine to treat COVID-19 was Luther News Agency (路德社) on YouTube on 29th JAN 2020.At that time, the whole world was immersed in shock and helplessness about the pandemic. (Luther News Agency (路德社) is a part of the whistleblower movement. Their news is not groundless, but based on the intelligence of a large number of Chinese whistleblowers familiar with the internal affairs of the CCP. Luther News Agency warned the world for the first time in its program on January 19, 2020 that COVID-19 is a biological weapon from the Chinese Communist Party’s laboratory. It is bound to spread from person to person, mutate strongly, and explode.)

Six days later, on February 4th, after the research team of China passed the approval of the Ethics Committee of Wuhan University People’s Hospital, the “Research on the Therapeutic Efficacy of Hydroxychloroquine for Novel Coronavirus (COVID-19)” was registered on the clinical trial platform (registration number: ChiCTR2000029559). As of February 17th, the hospital’s “hydroxychloroquine + basic treatment group” enrolled 20 patients with new coronary pneumonia and found that they all improved significantly after treatment with hydroxychloroquine.

On February 19th, 2020, the National Health Commission of China issued the “New Coronavirus Pneumonia Diagnosis and Treatment Plan (Trial Version 6)” which added chloroquine phosphate (500 mg for adults, twice a day) as a drug for the treatment of COVID-19. This is a question that needs attention. Why do they prefer to use chloroquine instead of hydroxychloroquine, which has similar drug properties but lower side effects and is safer? Are these experts from the National Health Commission of China ignorant or intentional? If it is intentional, why do they not want the public to know about hydroxychloroquine sulfate?

Although as of today, Chinese officials still do not recommend hydroxychloroquine as a standard drug for the treatment of COVID-19, in fact the CCP has been using it in secret. According to internal intelligence sources, senior CCP officials have secretly taken hydroxychloroquine as a preventive drug since December 26, 2019. At present, many front-line doctors in China also take hydroxychloroquine for a long time. The CCP regards hydroxychloroquine as a strategic asset, mass-produced and exported to countries associated with the CCP. China’s production of hydroxychloroquine in the first quarter of this year has exceeded that of the whole of last year. The Shanghai Pharmaceutical Group set a plan to produce 700 million tablets of hydroxychloroquine in April, which is a doubling of last year’s production.

Now let us review the following situation of the use of hydroxychloroquine sulfate in the world since the outbreak of the pandemic.

On March 21, the team of French scientist Didier Raoultapublished a clinical research paper in the scientific journal “International Journal of Antimicrobial Agents”, which showed that hydroxychloroquine sulfate has a significant effect on the treatment of COVID-19 patients, especially the negative conversion ratio of patients receiving hydroxychloroquine and azithromycin combined treatment were 100%.

On March 30, a doctor in New York used hydroxychloroquine + azithromycin + zinc sulfate to successfully cure more than 500 COVID-19 patients, with a cure rate of 100%, and only 10% of patients had nausea and diarrhea.

Many countries, including India, South Korea, Costa Rica, the United Arab Emirates and Turkey, have successfully recommended hydroxychloroquine for its superior efficacy in the prevention and early treatment of CCP virus. Statistics from the third week of May show that the mortality rate of countries that use hydroxychloroquine as a preventive and early treatment drug is significantly lower than that of countries that do not use it.

More and more first-line doctors have shown the evidences about the effectiveness of HCQ for prevention and treatment of COVID-19. (It is recommended to check this link: twitter.com/himalaya_new which lists in detail the timeline for the use of hydroxychloroquine sulfate to prevent and treat COVID-19 around the world, with a lot of evidence provided by doctors and scientists.)

Contrary to the effective cases given by a large number of first-line doctors, some bureaucratic medical institutions led by WHO claimed that hydroxychloroquine has no obvious effect on the treatment of COVID-19 and even has strong side effects. But their research report is obviously misleading. For example, the treatment group is severely ill patients, while the control group is mildly ill patients. There are even some reports showing that they overdose hydroxychloroquine to critically ill patients, causing the heart burden of critically ill patients to increase, and this has become evidence of the side effects of hydroxychloroquine.

Whether or not to use hydroxychloroquine to treat COVID-19 is not a difficult question to judge, but today’s debate on hydroxychloroquine are no longer a medical issue, but a political issue, and even more a matter of benefit distribution.

When President Trump first recommended the use of hydroxychloroquine to treat COVID-19 on March 19, he became a target of public criticism. Obviously, this moved the cheese of the pharmaceutical giant. The global pandemic has brought huge wealth to pharmaceutical giants. New drugs, ventilators, testing agents, protective equipment, vaccines, etc. are enough to make huge amounts of money for the upstream and downstream of the entire medical chain, although this is based on the lives and money of countless taxpayers. But all these was changed by hydroxychloroquine. A box of HCQ with 100 tablets for only 37 dollars can both prevent and treat COVID-19. If the whole world starts to use hydroxychloroquine to against the pandemic, then this feast of medical capital will be over.

If this pandemic is a biological war, then the current political struggle for hydroxychloroquine within the United States is tantamount to fighting each other in the face of the real enemy. On the one hand, the CCP keeps releasing the virus, on the other hand, the United States knows that there is an antidote but does not use it. The war that should have ended long ago killed countless Americans in a sad political game.

All should unite and urge the government to list hydroxychloroquine sulfate as an over-the-counter drug. In this pandemic, we must save ourselves, get rid of bureaucratic manipulation, and get our lives back on track.